CHORIORETINAL INFLAMMATORY DISEASES - Noninfectious Causes
Vogt-Koyanagi-Harada disease (VKH) currently is considered to be a cell-mediated autoimmune disease directed against melanocytes, that affects pigmented structures. Inflammation and loss of melanocytes have been described in a number of tissues, including the skin, inner ear, meninges, and uvea. In this inflammatory condition of autoimmune nature cytotoxic T cell target melanocytes in genetically susceptible individuals.
VKH is one of the most common causes of uveitis in orientals . Females are more commonly affected than males. The prodromal stage, preceding the acute uveitic stage by a few days, may mimic a viral infection.
Cutaneous manifestations include alopecia, poliosis and vitiligo. Ocular early manifestations of VKH include panuveitis with diffuse choroiditis, which may include serous retinal detachment...