Proliferative Diabetic Retinopathy in Type 1 Diabetes
Diabetes is a worldwide epidemic disease. In recent decades it has progressed from a disease affecting people primarily in developed countries, to a global phenomenon. Today diabetic retinopathy is a major cause of blindness in adult patients.
The eye is one of the target organs of this multisystemic disease. Diabetic retinopathy is nothing more than a compromise of the retinal microcirculation. The chronic exposure to hyperglycemia determines a number of biochemical and consequently histological changes
Initially, selective loss of pericytes, basement membrane thickening, as well as a diverse number of hematologic abnormalities, generate capillary occlusion, microaneurysm formation, dilation and beading of retinal veins as well as retinal ischemia.
A compromise of the endothelial barrier function...