Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an inflammatory disorder affecting the retina, retinal pigment epithelium (RPE), and choroid, leading to rapid loss of central and paracentral vision. It is more likely to affect healthy patients of 20-40-years of age after a systemic infection.
The exact pathological origin of APMPPE remains unknown, but is believed to be a hypersensitivity-induced vasculitis and represents a primary obstruction of the choroidal circulation with secondary RPE degeneration.
General symptoms include metamorphopsia, photopsia, scotomas, and blurred vision.
Fundus examination reveals multiple yellow-white placoid subretinal lesions of the posterior pole, usually bilateral and asymmetric. Fluorescein angiogram shows typically early-stage hypofluorescent...
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an inflammatory disorder affecting the retina, retinal pigment epithelium (RPE), and choroid, leading to rapid loss of central and paracentral vision. It is more likely to affect healthy patients of 20-40-years of age after a systemic infection.
The exact pathological origin of APMPPE remains unknown, but is believed to be a hypersensitivity-induced vasculitis and represents a primary obstruction of the choroidal circulation with secondary RPE degeneration.
General symptoms include metamorphopsia, photopsia, scotomas, and blurred vision.
Fundus examination reveals multiple yellow-white placoid subretinal lesions of the posterior pole, usually bilateral and asymmetric. Fluorescein angiogram shows typically early-stage hypofluorescent placoid areas and late-stage hyperfluorescent lesions.
It resolves in weeks to months but leaves scattered areas of RPE atrophy and hyperplasia.
Differential Diagnosis:
- Multifocal Choroiditis
- Sarcoidosis
- Vogt-Koyanagi-Harada Disease
- White Dot Syndromes
