{"id":74063,"date":"2021-11-23T16:41:13","date_gmt":"2021-11-23T16:41:13","guid":{"rendered":"https:\/\/www.atlasrleye.com\/syndrome-de-senior-loken\/"},"modified":"2025-07-15T00:15:55","modified_gmt":"2025-07-15T00:15:55","slug":"syndrome-de-senior-loken","status":"publish","type":"page","link":"https:\/\/www.atlasrleye.com\/fr\/syndrome-de-senior-loken\/","title":{"rendered":"SYNDROME DE SENIOR-LOKEN"},"content":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=\u00a0\u00bbSYNDROMES ET DYSTROPHIES R\u00c9TINIENNES\u00a0\u00bb font_container=\u00a0\u00bbtag:h5|font_size:22px|text_align:center|color:%23000000″ use_theme_fonts=\u00a0\u00bbyes\u00a0\u00bb link=\u00a0\u00bburl:https%3A%2F%2Fwww.atlasrleye.com%2Ffr%2Fatlas%2F%231636632807269-1444524b-3ed4|\u00a0\u00bb][vc_text_separator title=\u00a0\u00bb\u00a0\u00bb i_icon_fontawesome=\u00a0\u00bbfas fa-eye\u00a0\u00bb i_color=\u00a0\u00bbcustom\u00a0\u00bb i_size=\u00a0\u00bblg\u00a0\u00bb color=\u00a0\u00bbcustom\u00a0\u00bb border_width=\u00a0\u00bb8″ css=\u00a0\u00bb.vc_custom_1637080776101{margin-bottom: -5px !important;}\u00a0\u00bb add_icon=\u00a0\u00bbtrue\u00a0\u00bb accent_color=\u00a0\u00bb#bababa\u00a0\u00bb i_custom_color=\u00a0\u00bb#bababa\u00a0\u00bb][vc_custom_heading source=\u00a0\u00bbpost_title\u00a0\u00bb font_container=\u00a0\u00bbtag:h1|font_size:44px|text_align:center|color:%235f1b52″ use_theme_fonts=\u00a0\u00bbyes\u00a0\u00bb]

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Le syndrome de Senior-Loken (amaurose cong\u00e9nitale de Leber avec nephrophtisies) est une maladie rare, ciliopathique et autosomique r\u00e9cessive, caract\u00e9ris\u00e9e par nephrophtisies et dystrophie de c\u00f4nes et b\u00e2tonnets d’apparition pr\u00e9coce, de type amaurose cong\u00e9nitale de Leber. Les anomalies r\u00e9tiniennes se manifestent par la c\u00e9cit\u00e9 cong\u00e9nitale ou la r\u00e9tinopathie pigmentaire. Le g\u00e8ne le plus fr\u00e9quemment mut\u00e9 dans ce syndrome est le IQCB1\/NPHP5.<\/p>\n

Le fond pr\u00e9sente spicules pigment\u00e9es abondantes dans la r\u00e9tine p\u00e9riph\u00e9rique, associ\u00e9es \u00e0 l’ atrophie de l’\u00e9pith\u00e9lium pigmentaire de la r\u00e9tine.<\/p>\n

Les manifestations cliniques incluent une ataxie c\u00e9r\u00e9belleuse et des anomalies squelettiques (\u00e9piphyse en forme de c\u00f4ne).<\/p>\n<\/div>\n

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Cas Cliniques<\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=\u00a0\u00bb.vc_custom_1752538324109{margin-bottom: 10px !important;}\u00a0\u00bb]<\/p>\n

Cas Cliniques<\/span><\/strong><\/h1>\n

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Cas Clinique 1<\/a><\/h4>\n

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0<\/h3><\/div> <\/div> <\/div> [\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=\u00a0\u00bbSYNDROMES ET DYSTROPHIES R\u00c9TINIENNES\u00a0\u00bb font_container=\u00a0\u00bbtag:h5|font_size:22px|text_align:center|color:%23000000″ use_theme_fonts=\u00a0\u00bbyes\u00a0\u00bb link=\u00a0\u00bburl:https%3A%2F%2Fwww.atlasrleye.com%2Ffr%2Fatlas%2F%231636632807269-1444524b-3ed4|\u00a0\u00bb][vc_text_separator title=\u00a0\u00bb\u00a0\u00bb i_icon_fontawesome=\u00a0\u00bbfas fa-eye\u00a0\u00bb i_color=\u00a0\u00bbcustom\u00a0\u00bb i_size=\u00a0\u00bblg\u00a0\u00bb color=\u00a0\u00bbcustom\u00a0\u00bb border_width=\u00a0\u00bb8″ css=\u00a0\u00bb.vc_custom_1637080776101{margin-bottom: -5px !important;}\u00a0\u00bb add_icon=\u00a0\u00bbtrue\u00a0\u00bb accent_color=\u00a0\u00bb#bababa\u00a0\u00bb i_custom_color=\u00a0\u00bb#bababa\u00a0\u00bb][vc_custom_heading source=\u00a0\u00bbpost_title\u00a0\u00bb font_container=\u00a0\u00bbtag:h1|font_size:44px|text_align:center|color:%235f1b52″ use_theme_fonts=\u00a0\u00bbyes\u00a0\u00bb][\/vc_column][\/vc_row][vc_row][vc_column width=\u00a0\u00bb3\/4″][vc_column_text] Le syndrome de Senior-Loken (amaurose cong\u00e9nitale de Leber avec nephrophtisies) est une maladie rare, ciliopathique […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-74063","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/pages\/74063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/comments?post=74063"}],"version-history":[{"count":8,"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/pages\/74063\/revisions"}],"predecessor-version":[{"id":118087,"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/pages\/74063\/revisions\/118087"}],"wp:attachment":[{"href":"https:\/\/www.atlasrleye.com\/fr\/wp-json\/wp\/v2\/media?parent=74063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}