{"id":75365,"date":"2021-11-22T13:39:04","date_gmt":"2021-11-22T13:39:04","guid":{"rendered":"https:\/\/www.atlasrleye.com\/non-proliferative-diabetic-retinopathy\/"},"modified":"2025-07-15T22:09:32","modified_gmt":"2025-07-15T22:09:32","slug":"non-proliferative-diabetic-retinopathy","status":"publish","type":"page","link":"https:\/\/www.atlasrleye.com\/en\/non-proliferative-diabetic-retinopathy\/","title":{"rendered":"NON-PROLIFERATIVE DIABETIC RETINOPATHY"},"content":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=”DIABETIC RETINOPATHY” font_container=”tag:h5|font_size:22px|text_align:center|color:%23000000″ use_theme_fonts=”yes” link=”url:https%3A%2F%2Fwww.atlasrleye.com%2Fen%2Fatlas%2F%231636632808670-a28fb046-8c67|”][vc_text_separator title=”” i_icon_fontawesome=”fas fa-eye” i_color=”custom” i_size=”lg” color=”custom” border_width=”8″ css=”.vc_custom_1637080776101{margin-bottom: -5px !important;}” add_icon=”true” accent_color=”#bababa” i_custom_color=”#bababa”][vc_custom_heading source=”post_title” font_container=”tag:h1|font_size:44px|text_align:center|color:%235f1b52″ use_theme_fonts=”yes”]

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Diabetes is a worldwide epidemic disease. In recent decades it has progressed from a disease affecting people primarily in developed countries, to a global phenomenon. Today diabetic retinopathy is a major cause of blindness in adult patients.<\/p>\n

The eye is one of the target organs of this multisystemic disease. Diabetic retinopathy is nothing more than a compromise of the retinal microcirculation. The chronic exposure to hyperglycemia determines a number of biochemical and consequently histological changes. Initially, selective loss of pericytes, basement membrane thickening, as well as a diverse number of hematologic abnormalities, generate capillary occlusion, microaneurysm formation, dilation and beading of retinal veins as well as retinal ischemia.<\/p>\n

A compromise of the endothelial barrier function allows vascular leakage, originating retinal edema and deposition of hard exsudates. Areas of retinal ischemia generate vasoproliferative factors (mainly vascular endothelium growth factor – VEGF) that later stimulate the growth of neovessels.<\/p>\n

According to fundoscopic findings, diabetic retinopathy may be divided in non-proliferative and proliferative diabetic retinopathy, based on the presence of neovascularization. The most commonly used classification scale is the International Clinical Diabetic Retinopathy Disease Severity Scale:<\/p>\n<\/div>\n

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No apparent retinopathy: no abnormalities<\/p>\n