{"id":73577,"date":"2021-11-24T11:30:58","date_gmt":"2021-11-24T11:30:58","guid":{"rendered":"https:\/\/www.atlasrleye.com\/congenital-hypertrophy-of-the-retinal-pigment-epithelium\/"},"modified":"2025-07-15T16:37:03","modified_gmt":"2025-07-15T16:37:03","slug":"congenital-hypertrophy-of-the-retinal-pigment-epithelium","status":"publish","type":"page","link":"https:\/\/www.atlasrleye.com\/en\/congenital-hypertrophy-of-the-retinal-pigment-epithelium\/","title":{"rendered":"CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM"},"content":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=”RETINAL AND CHOROIDAL TUMORS” font_container=”tag:h5|font_size:22px|text_align:center|color:%23000000″ use_theme_fonts=”yes” link=”url:https%3A%2F%2Fwww.atlasrleye.com%2Fen%2Fatlas%2F%231636632883096-c2c9ed67-9b78|”][vc_text_separator title=”” i_icon_fontawesome=”fas fa-eye” i_color=”custom” i_size=”lg” color=”custom” border_width=”8″ css=”.vc_custom_1637080776101{margin-bottom: -5px !important;}” add_icon=”true” accent_color=”#bababa” i_custom_color=”#bababa”][vc_custom_heading source=”post_title” font_container=”tag:h1|font_size:44px|text_align:center|color:%235f1b52″ use_theme_fonts=”yes”]

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Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is an uncommon benign fundus lesion, which is usually asymptomatic and detected on routine ophthalmic examination.<\/p>\n

CHRPE is the result of diffuse proliferation of pigment epithelial cells and is a well-defined lesion which is flat or slightly elevated, round, solitary, dark brown-to-black in colour, and has scalloped edges. In older patients, it may have foci of depigmentation.<\/p>\n

No treatment is required, but if the lesion increases in diameter or gives rise to an elevated nodule, this may represent an adenoma or adenocarcinoma.<\/p>\n

CHRPE can present in the context of familial adenomatous polyposis (Gardner’s syndrome), albeit, bilaterally with multifocal, smaller, ovoid lesions.<\/p>\n

In fluorescein angiogram lesions have blackened hypofluorescence noted in all phases.<\/p>\n

Differential Diagnosis<\/p>\n