CHORIORETINAL INFLAMMATORY DISEASES - Noninfectious Causes
Sympathetic ophthalmia (SO) is a bilateral, diffuse, granulomatous, T-cell-mediated non-necrotizing panuveitis in one eye (sympathizing eye), following a surgical or accidental trauma of the other eye (exciting eye), after a variable latency period.
SO represents 2% of all uveitis cases. Incidence has been estimated to be up to 0.5% in eyes with nonsurgical trauma and 1/10000 cases after intraocular surgery.
The latency period can be as low as 5 days and as late as 50 years. 80% of cases occur 3 weeks to 3 months after injury and 90% up to 1 year.
It is associated with traumatic uveal incarceration or prolapse. This appears to cause a delayed type hypersensitivity to previously sequestered antigens localized on the retinal pigment epithelium or on uveal melanocytes. Certain types of human leukocyte...