The spectrum of intraocular lymphoid tumors ranges from benign reactive lymphoid hyperplasia to various types of malignant lymphoma.
Intraocular lymphoma is commonly a non-Hodgkin’s large B cell lymphoma of the eye and the CNS.
The ocular findings include large clumps of cells in the vitreous, and the fundus examination is significant for multifocal, large, yellow, sub-retinal and sub-RPE infiltrative lesions.
Patients with intraocular lymphoma can be divided into several distinct subgroups, associated with: central nervous system non-Hodgkin’s lymphoma, systemic non-Hodgkin’s lymphoma, acquired immunodeficiency syndrome, and other rare forms of systemic lymphoma.
DIFFERENTIAL DIAGNOSIS of Intraocular-CNS Lymphoma:
Subretinal and Sub-RPE...
The spectrum of intraocular lymphoid tumors ranges from benign reactive lymphoid hyperplasia to various types of malignant lymphoma.
Intraocular lymphoma is commonly a non-Hodgkin’s large B cell lymphoma of the eye and the CNS.
The ocular findings include large clumps of cells in the vitreous, and the fundus examination is significant for multifocal, large, yellow, sub-retinal and sub-RPE infiltrative lesions.
Patients with intraocular lymphoma can be divided into several distinct subgroups, associated with: central nervous system non-Hodgkin’s lymphoma, systemic non-Hodgkin’s lymphoma, acquired immunodeficiency syndrome, and other rare forms of systemic lymphoma.
DIFFERENTIAL DIAGNOSIS of Intraocular-CNS Lymphoma:
Subretinal and Sub-RPE Infiltrates
- Acute posterior multifocal placoid pigment epitheliopathy
- Amelanotic choroidal melanoma
- Bilateral diffuse uveal melanocytic proliferation
- Birdshot retinochoroidopathy
- Choroidal granuloma (e.g., sarcoidosis, tuberculosis)
- Choroidal metastasis
- Diffuse unilateral subacute neuroretinitis
- Fundus flavimaculatus
- Multifocal choroiditis
- Multiple evanescent white dot syndrome
- Pneumocystis choroiditis
- Sympathetic ophthalmia
- Vogt-Koyanagi-Harada syndrome
Retinal and Retinal Vascular Infiltrates
- Fungal retinochoroiditis
- Retinal periphlebitis (e.g., sarcoidosis, toxoplasmosis)
- Retinal vascular occlusion
- Retinal vasculitis (e.g., frosted branch angiitis, Behçet’s disease)
- Toxoplasmosis
- Viral retinitis (e.g., acute retinal necrosis, cytomegalovirus retinitis)
Vitreous
- Amyloidosis
- Intermediate or posterior uveitis
- Old vitreous hemorrhage
- Senile vitritis
- Optic nerve
- Infiltrative disease (e.g., leukemia, metastasis, granuloma)
- Optic disc edema
